Amyloidosis in the course of multiple myeloma

The amyloidoses are group of heterogeneous disorders, in which synthesized and secreted proteins, as a soluble molecules, are formed into insoluble, fibrillar tissue deposits, leading to organ dysfunction. Classification now is based on the chemical nature of the fibrillar component of the deposits....

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Published inPolskie archiwum medycyny wewne̦trznej Vol. 113; no. 4; p. 341
Main Authors Mazur, Grzegorz, Usnarska-Zubkiewicz, Lidia, Wróbel, Tomasz, Biedroń, Monika, Nowicka, Jadwiga, Ganczarski, Grzegorz, Kuliczkowski, Kazimierz
Format Journal Article
LanguagePolish
Published Poland 01.04.2005
Subjects
Adult
Aged
Aged, 80 and over
Amyloid - metabolism
Amyloidosis - complications
Female
Humans
Male
Middle Aged
Multiple Myeloma - complications
Serum Amyloid A Protein - metabolism
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Summary:The amyloidoses are group of heterogeneous disorders, in which synthesized and secreted proteins, as a soluble molecules, are formed into insoluble, fibrillar tissue deposits, leading to organ dysfunction. Classification now is based on the chemical nature of the fibrillar component of the deposits. One of these is light-chain amyloidosis (AL). The aim of the study was to describe of multiple myeloma patients and amyloidosis. The study group consisted of 45 patients (16 men and 29 women). The diagnosis was made by fine-needle aspiration of subcutaneous fat and then staining the tissue with Congo red. We also analyse the concentration of the serum SAA. We analyse the most characteristic features of AL as hearth failure, proteinuria, renal failure, carpal tunnel syndrome, hepatosplenomegaly, macroglossia and orthostatic hypotension. Among the multiple myeloma patients we found 17 with AL amyloid and 35 persons with elevated concentration of the serum SAA. The most frequent symptoms were related with renal failure and heart failure.
ISSN:1897-9483