Biological activity of a new series of tertiary alcohols

The in vitro antimicrobial activity of a new series of synthetic fluorine-substituted triaryl alcohols against the human pathogens Staphylococcus aureus, Escherichia coli, and Candida albicans was studied with the aim of overcoming multiple drug resistance and improving the clinical usefulness of an...

Full description

Saved in:
Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 31; no. 4; p. 441
Main Authors da Costa, M Rute G, Curto, M Joao M, Furtado, Olivia R, Savluchinske Feio, Sonia, Roseiro, Jose C
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2005
Subjects
Alcohols - chemistry
Alcohols - pharmacology
Anti-Bacterial Agents - pharmacology
Antifungal Agents - pharmacology
Benzene Derivatives - chemistry
Benzene Derivatives - pharmacology
Hydrocarbons, Fluorinated - chemistry
Hydrocarbons, Fluorinated - pharmacology
Microbial Sensitivity Tests
Molecular Structure
Structure-Activity Relationship
Online AccessGet more information

Cover

More Information
Summary:The in vitro antimicrobial activity of a new series of synthetic fluorine-substituted triaryl alcohols against the human pathogens Staphylococcus aureus, Escherichia coli, and Candida albicans was studied with the aim of overcoming multiple drug resistance and improving the clinical usefulness of antimicrobial drugs. The nature and positions of substituents attached to aromatic rings, as well as their electronegativities and sizes, seem to affect the preferred molecular conformations and, hence, the binding of the compounds to the corresponding cell receptors.
ISSN:0132-3423