Neuroprotective effect of N-acylethanolamines in chronic morphine dependence. I. Rat brain phospholipids as a target of their action

The influence of saturated and unsaturated N-acylethanolamines (NAEs) mixture on the rat brain lipid composition under the chronic morphine dependence was studied. It was shown that the long-term administration of NAE to rats with experimental morphine dependence restored the morphine-induced altera...

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Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 76; no. 5; p. 123
Main Authors Hula, N M, Marhitych, V M, Artamonov, M V, Zhukov, O D, Horid'ko, T M, Klimashevs'kyĭ, V M
Format Journal Article
LanguageUkrainian
Published Ukraine 01.09.2004
Subjects
Animals
Brain - drug effects
Brain - metabolism
Chronic Disease
Disease Models, Animal
Ethanolamines - therapeutic use
Male
Morphine Dependence - drug therapy
Morphine Dependence - metabolism
Neuroprotective Agents - therapeutic use
Oxidative Stress - drug effects
Phospholipids - metabolism
Rats
Rats, Wistar
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Summary:The influence of saturated and unsaturated N-acylethanolamines (NAEs) mixture on the rat brain lipid composition under the chronic morphine dependence was studied. It was shown that the long-term administration of NAE to rats with experimental morphine dependence restored the morphine-induced alterations of the brain phospholipid composition. This effect can probably be explained by a fatty acyl transfer from NAE to sn-1 position of some brain glycerophospholipids. Another reason of NAE beneficial effect could be due to its antioxidative property, thus providing the remodelling of phospholipid composition. The restoration of the brain essential phospholipids is associated with the decline in morphine consumption in rats with experimental morphine dependence. The mechanism of this phenomenon requires further investigations.