Local failure-related factors of esophageal carcinoma after concurrent chemoradiotherapy

• Published in: Ai zheng = Aizheng = Chinese journal of cancer Vol. 24; no. 4; p. 498
• Main Authors: Chen, Er-Cheng, Liu, Meng-Zhong, Hu, Yong-Hong, Liu, Hui, Li, Qiao-Qiao, Cai, Ling, Huang, Ying, Lin, Huan-Xin, Wang, Han-Yu, Cui, Nian-Ji
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2005
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cisplatin - administration & dosage; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - pathology; Esophageal Neoplasms - radiotherapy; Female; Fluorouracil - administration & dosage; Follow-Up Studies; Humans; Logistic Models; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Radiation Dosage; Remission Induction; Treatment Failure

Concurrent chemoradiotherapy is the standard treatment for unresectable esophageal carcinoma. Local failure and recurrence are main reasons of treatment failure. This study was to discuss the factors related with local failure and recurrence of unresectable esophageal carcinoma after concurrent chemoradiotherapy. Records of 132 patients with esophageal carcinoma, treated with concurrent chemotherapy in our hospital from Jan. 1996 to Dec. 2003, were reviewed. The patients received the first cycle of chemotherapy at the beginning of radiotherapy, and the second cycle of chemotherapy when radiation dose escalated to 40 Gy. Local failure-related factors were analyzed by binary logistic regression. To the terminal of follow-up, of the 132 patients, 54 had local failure or in-fields recurrence, 20 had in-fields recurrence and lymph nodes or distant metastasis, 5 had out-fields recurrence. Logistic regression analysis showed that short-term effect and irradiation dose were correlated with local failure and recurrenc