External radiation and combined transcatheter arterial chemoembolization for unresectable primary liver cancer

Transcatheter arterial chemoembolization (TACE) is the routine treatment for unresectable primary liver cancer, but 3-year survival rate of patients received TACE alone is only about 20%. This research was to evaluate efficacy of external radiotherapy (RT) combined with TACE on unresectable primary...

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Bibliographic Details
Published inAi zheng = Aizheng = Chinese journal of cancer Vol. 24; no. 1; p. 82
Main Authors Liu, Meng-Zhong, Wang, Xiu-Shen, Cai, Ling, Gu, Mo-Fa, Liu, Hui, Li, Qun, Cui, Nian-Ji, Zhang, Ya-Qi, Li, Guo-Hui, Li, Jin-Qing
Format Journal Article
LanguageChinese
Published China 01.01.2005
Subjects
Adult
Aged
alpha-Fetoproteins - metabolism
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Carboplatin - administration & dosage
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - radiotherapy
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic - methods
Combined Modality Therapy
Epirubicin - administration & dosage
Female
Humans
Liver Neoplasms - blood
Liver Neoplasms - radiotherapy
Liver Neoplasms - therapy
Male
Middle Aged
Mitomycin - administration & dosage
Particle Accelerators
Survival Rate
Treatment Outcome
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Summary:Transcatheter arterial chemoembolization (TACE) is the routine treatment for unresectable primary liver cancer, but 3-year survival rate of patients received TACE alone is only about 20%. This research was to evaluate efficacy of external radiotherapy (RT) combined with TACE on unresectable primary live cancer. From Jun. 1994 to Apr. 2002, 114 patients with unresectable primary liver cancer were non-randomized to receive TACE plus RT (54 patients), or TACE alone (60 patients) as control. For TACE, after skiagram confirmed catheterization, suspension of 300 mg of carboplatin, 50-60 mg of epirubicin, 14-20 mg of mitomycin, and 10-30 ml of iodized oil was perfused into hepatic arteries, 1-2 mm of Gelfoam particles was given to embolize hepatic arteries according to blood supply conditions of tumors, this process was repeated every 4-8 weeks. Either group was treated with 1-4 sessions of TACE. In TACE+RT group, patients received radiation on tumor and generous margin 21-28 days after TACE. The radiation dose was