Hepatitis B and C virus infection and the hepatocellular carcinoma in the East Amazon, Brazil

In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV...

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Published inRevista da Sociedade Brasileira de Medicina Tropical Vol. 37 Suppl 2; p. 47
Main Authors Miranda, Esther Castello Branco Mello, Moia, Lizomar de Jesus Pereira, Amaral, Ivanete do Socorro Abraçado, Barbosa, Maria Silvia de Brito, Conde, Simone Regina Souza da Silva, de Araújo, Marialva Tereza Ferreira, da Cruz, Ermelinda do Rosário Moutinho, Demachki, Samia, Bensabath, Gilberta, Soares, Manoel do Carmo Pereira
Format Journal Article
LanguagePortuguese
Published Brazil 2004
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Brazil
Carcinoma, Hepatocellular - virology
Child
DNA, Viral - analysis
Female
Hepatitis B - complications
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis C - complications
Hepatitis C Antibodies - blood
Humans
Liver Neoplasms - virology
Male
Middle Aged
Polymerase Chain Reaction
RNA, Viral - analysis
Brazil
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Summary:In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed.
ISSN:0037-8682