Statin-induced rhabdomyolysis and renal failure: also with fluvastatine

Hydroximetilglutaril-coenzima A reductase inhibitors (statin) have the potential to cause rhabdomyolysis. However, fluvastatin is rarely associated with rhabdomyolysis when compared to other statins. Differences in biochemical and pharmacokinetic properties between fluvastatin and the other statins...

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Bibliographic Details
Published inAnales de medicina interna (Madrid, Spain : 1984) Vol. 21; no. 5; p. 235
Main Authors Lado Lado, F L, Rodríguez Moreno, C, Cinza Sajurjo, S, Durán Parrondo, C, Pazo Núñez, M, Lois Pernas, A, Masa Vázquez, L
Format Journal Article
LanguageSpanish
Published Spain 01.05.2004
Subjects
Acute Kidney Injury - chemically induced
Aged
Fatty Acids, Monounsaturated - adverse effects
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Indoles - adverse effects
Rhabdomyolysis - chemically induced
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Summary:Hydroximetilglutaril-coenzima A reductase inhibitors (statin) have the potential to cause rhabdomyolysis. However, fluvastatin is rarely associated with rhabdomyolysis when compared to other statins. Differences in biochemical and pharmacokinetic properties between fluvastatin and the other statins have been invocated in order to explain the apparent comparative safety of fluvastatin. We present a case of rhabdomyolysis with acute renal failure in a patient receiving fluvastatin and, following the Karch-Lasagne algorithm, we present evidence that this case was an adverse reactions to fluvastatin.
ISSN:0212-7199