Biological characteristics of strains of lactobacilli, promising for use as eubiotics

In the course of in vitro studies 3 Lactobacillus strains with pronounced antagonistic activity against some pathogenic and opportunistic bacteria (shigellae, enteropathogenic Escherichia, Proteus, staphylococci) were selected. In experiments on germ-free rats faint colonization by L. plantarum 37 w...

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Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 3; p. 17
Main Authors Gorskaia, E M, Liz'ko, N N, Lentsner, A A, Bondarenko, V M, Sokolova, K Ia, Likhacheva, A Iu
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1992
Subjects
Adult
Animals
Bacterial Infections - therapy
Enterobacteriaceae - pathogenicity
Humans
Intestines - microbiology
Intestines - pathology
Lactobacillus
Rats
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Summary:In the course of in vitro studies 3 Lactobacillus strains with pronounced antagonistic activity against some pathogenic and opportunistic bacteria (shigellae, enteropathogenic Escherichia, Proteus, staphylococci) were selected. In experiments on germ-free rats faint colonization by L. plantarum 37 was observed in the small intestine, as well as in the large intestine when low doses of these bacilli were introduced into the gastrointestinal tract of the animals. In vitro experiments demonstrated the decreased growth rate of this strain. The prophylactic administration of two eubiotic strains, L. plantarum 37 and L. fermentum 39, simultaneously with chloramphenicol to primates inhibited the growth of opportunistic bacteria, though L. fermentum 39 excessively suppressed the content of Escherichia coli in the enterobacterial population. The optimum biological effect was achieved with the therapeutic use of these three strains for the correction of dysbiotic disturbances caused by the administration of tetracycline in volunteers.
ISSN:0372-9311