Gene therapy for the treatment of patients with brain gliomas

The prognosis of patients with brain gliomas remains poor despite the use of advanced surgical techniques, radio- and chemotherapy. In this respect, gene engineering techniques altering the glioma genome in order to regulate the function of key genes involved in cancerogenesis seem to be promising....

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Bibliographic Details
Published inNeurologia i neurochirurgia polska Vol. 38; no. 1; p. 45
Main Authors Słowiński, Jerzy, Mrówka, Ryszard
Format Journal Article
LanguagePolish
Published Poland 01.01.2004
Subjects
Brain Neoplasms - genetics
Carrier Proteins - genetics
Epidermal Growth Factor - genetics
Genetic Therapy - methods
Glioma - genetics
Humans
Intercellular Signaling Peptides and Proteins
Molecular Biology - methods
Protein Kinase C - genetics
Proteins - genetics
Receptors, Platelet-Derived Growth Factor - genetics
Transforming Growth Factor beta - genetics
Vascular Endothelial Growth Factor A - genetics
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Summary:The prognosis of patients with brain gliomas remains poor despite the use of advanced surgical techniques, radio- and chemotherapy. In this respect, gene engineering techniques altering the glioma genome in order to regulate the function of key genes involved in cancerogenesis seem to be promising. The premise for applying a gene therapy in patients with brain gliomas is described, together with basic strategies and results of hitherto performed experimental and clinical studies, mostly with the use of virus vectors. The rapid progress in molecular techniques may enable to overcome methodological problems related to the introduction of the therapeutic gene into the target cell, and thus to improve so far unsatisfactory results of glioma gene therapy. The important role of a neurosurgeon in the process of precise gene vector application to the tumour area should not be underestimated.
ISSN:0028-3843