Estradiol-17beta activates corticosteroid synthesis and inhibits proliferation in cultured porcine adrenocortical cells

The influence of estradiol-17 beta on corticosteroids production and cell proliferation were studied in the cultured pig adrenocortical cells. Estradiol-17 beta considerably increased steroidogenesis, but inhibited cell proliferation. It is speculated, that cAMP mediated estradiol-17 beta effects in...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 75; no. 1; p. 29
Main Authors Mikosha, A S, Kovzun, E I, Grinchenko, E N
Format Journal Article
LanguageRussian
Published Ukraine 01.01.2003
Subjects
Adrenal Cortex - cytology
Adrenal Cortex - metabolism
Adrenal Cortex Hormones - biosynthesis
Animals
Cell Division - drug effects
Cells, Cultured
Estradiol - pharmacology
Swine
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Summary:The influence of estradiol-17 beta on corticosteroids production and cell proliferation were studied in the cultured pig adrenocortical cells. Estradiol-17 beta considerably increased steroidogenesis, but inhibited cell proliferation. It is speculated, that cAMP mediated estradiol-17 beta effects in the adrenal cells.