Refractory effect and alloimmunization after transfusion of thrombocytes

The authors discuss possible ways for prevention of alloimmunization with HLA-antigen in acute leukemia patients after platelet transfusions. Prevention or delay of HLA-alloimmunization is possible when platelets of single random donor are used instead of pooled random donor platelets for transfusio...

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Bibliographic Details
Published inGematologiia i transfuziologiia Vol. 37; no. 2; p. 16
Main Authors Volkova, R I, Agranenko, V A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1992
Subjects
Anaphylaxis - etiology
Anaphylaxis - immunology
Anaphylaxis - prevention & control
Blood Donors
Blood Platelets - immunology
Hemofiltration - methods
Hemorrhage - immunology
Hemorrhage - therapy
HLA Antigens - immunology
Humans
Leukemia - immunology
Leukemia - therapy
Leukocyte Count
Leukocytes - immunology
Platelet Count
Platelet Transfusion
Transfusion Reaction
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Summary:The authors discuss possible ways for prevention of alloimmunization with HLA-antigen in acute leukemia patients after platelet transfusions. Prevention or delay of HLA-alloimmunization is possible when platelets of single random donor are used instead of pooled random donor platelets for transfusions. The effect of leucocyte removal from platelet concentrates and ultraviolet irradiation of platelet concentrates under conditions of blood bank on alloimmunization and refractoriness incidence has been considered.
ISSN:0234-5730