Tetanus responses under rapid bath solution change: electrotonic depolarization of transverse tubules may release Ca2+ from sarcoplasmic reticulum of Rana japonica skeletal muscle

1. Single skeletal muscle fibers were transferred from a normal Ringer solution to Na+ ion free solution, and vice versa, and tetanus responses were recorded immediately after the transfer. 2. Fractional tetanus tension recorded immediately after the displacement from the Na+ ion free solution to no...

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Bibliographic Details
Published inComparative biochemistry and physiology. Comparative physiology Vol. 103; no. 4; p. 661
Main Authors Fujishiro, N, Kawata, H
Format Journal Article
LanguageEnglish
Published England 01.12.1992
Subjects
Action Potentials
Animals
Calcium - metabolism
Diffusion
Electric Stimulation
In Vitro Techniques
Membrane Potentials
Muscle Contraction
Muscles - metabolism
Muscles - physiology
Ranidae
Sarcoplasmic Reticulum - metabolism
Sodium - metabolism
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Summary:1. Single skeletal muscle fibers were transferred from a normal Ringer solution to Na+ ion free solution, and vice versa, and tetanus responses were recorded immediately after the transfer. 2. Fractional tetanus tension recorded immediately after the displacement from the Na+ ion free solution to normal Ringer solution was dependent on fiber diameter. 3. Diffusion of Na+ ions along the transverse tubules was simulated [apparent diffusion constant was 3.11 x 10(-6) (cm2/s)]. 4. Our results suggest that the electronic spreading of membrane potential, caused by an action potential in the transverse tubules, could release Ca2+ ions from sarcoplasmic reticulum.