Effect of a polyoxydonium immunoregulator on the biological properties of microorganisms

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 4; p. 74
• Main Authors: Kirillov, D A, Chaĭnikova, I N, Perunova, N B, Chelpachenko, O E, Pan'kov, A S, Smoliagin, A I, Valyshev, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.2003
• Subjects: Adjuvants, Immunologic - pharmacology; Anti-Bacterial Agents - pharmacology; Bacteria, Aerobic - drug effects; Bacteria, Aerobic - growth & development; Bacteria, Aerobic - metabolism; Bacteria, Anaerobic - drug effects; Bacteria, Anaerobic - growth & development; Bacteria, Anaerobic - metabolism; Complement Inactivator Proteins - metabolism; Enteritis - microbiology; Enzyme Inhibitors - metabolism; Fungi - drug effects; Fungi - metabolism; Humans; Microbial Sensitivity Tests; Muramidase - antagonists & inhibitors; Muramidase - metabolism; Organic Chemicals; Respiratory Tract Infections - microbiology
• ISSN: 0372-9311

The effect of the synthetic immunomodulator polyoxydonium (PO) on some biological properties of pathogenic bacteria (Shigella flexneri, Salmonella enteritidis), opportunistic bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacteroides fragilis, Peptostreptococcus anaerobius, Prevotella melaninogenica, Propionibacterium propionicum, Clostridium difficile) and fungi (Candida albicans), isolated during enteric infections, enteric dysbiosis, pyoinflammatory diseases, was evaluated in a number of in vitro experiments. The study revealed that the recommended therapeutic concentration of PO decreased antilysozyme activity (ALA) and the anticomplement activity in Klebsiella, Shigella, Propionibacterium, Clostridium, bacteroids, fungi of the genus Candida, but increased ALA in nonhemolytic Escherichia. Under the action of PO an increased sensitivity of the microorganisms under study to definite antibiotics of the lincosamide, fluoroquinolon, carbapenem and cephalosporin groups was noted. The data obtained in this study reveal one of the possible mechanisms of the corrective action of PO on the microbiocenosis of the intestine in dysbiosis, enteric infections and pyoinflammatory diseases.