Imbalance in the proteinase-inhibitor system in obstetric sepsis and septic shock

The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. T...

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Bibliographic Details
Published inKlinicheskaia laboratornaia diagnostika no. 7; p. 13
Main Authors Belova, L A, Ogloblina, O G, Satalkin, A A, Diugeev, A N, Fomin, M D, Kashina, L G, Kukharchuk, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2003
Subjects
alpha 1-Antichymotrypsin - blood
alpha 1-Antitrypsin - analysis
alpha-Macroglobulins - analysis
Endopeptidases - blood
Female
Humans
Obstetric Labor Complications - blood
Obstetric Labor Complications - diagnosis
Pregnancy
Protease Inhibitors - metabolism
Sepsis - blood
Sepsis - diagnosis
Shock, Septic - blood
Shock, Septic - diagnosis
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Summary:The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. The activity of alpha-macroglobulins was also by 2 times lower versus the controls, while the activity of alpha 1-antichymotrypsin and of an acid-stable inhibitor of trypsin was found to be higher by 20-30%. A degree of imbalance of proteinase/inhibitor depends on a disease severity.
ISSN:0869-2084