Pancreastatin secretion stimulation in healthy volunteers

According to animal studies pancreastatin (PST), a peptide that is secreted by numerous neroendocrine cells, inhibits insulin secretion and has a hyperglycaemic and glycogenolytic effect. However, physiologic role of PST in carbohydrate metabolism remains unclear. In order to determine the best stim...

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Published inPolskie archiwum medycyny wewne̦trznej Vol. 108; no. 6; p. 1185
Main Authors Zagórowicz, Edyta, Bak, Marianna, Siemińska, Jolanta, Muszyński, Jacek
Format Journal Article
LanguagePolish
Published Poland 01.12.2002
Subjects
Adult
Body Mass Index
Chromogranin A
Energy Intake
Female
Glucagon - pharmacology
Humans
Male
Pancreatic Hormones - blood
Pancreatic Hormones - metabolism
Pancreatic Hormones - secretion
Time Factors
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Summary:According to animal studies pancreastatin (PST), a peptide that is secreted by numerous neroendocrine cells, inhibits insulin secretion and has a hyperglycaemic and glycogenolytic effect. However, physiologic role of PST in carbohydrate metabolism remains unclear. In order to determine the best stimulus of PST secretion, four different stimulations of GI tract were carried out in 10 healthy volunteers: oral glucose loading test, intravenous glucose loading test, intravenous glucagon infusion and standard meal loading test. Serum PST concentration was measured radioimmunologically at established intervals after each stimulation. It was found that either oral or intravenous glucose loading test do not increase serum PST concentration; intravenous glucagon infusion decreases serum PST concentration and a standard meal increases serum PST concentration.
ISSN:1897-9483