Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior

• Published in: Ai zheng = Aizheng = Chinese journal of cancer Vol. 21; no. 6; p. 619
• Main Authors: Ji, She-qing, Hua, Ya-wei, Zhuang, Jing, Gao, Yang, Kong, Ye, Han, Shao-liang, Shao, Yong-fu
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2002
• Subjects: Cyclooxygenase 2; Humans; Isoenzymes - biosynthesis; Membrane Proteins; Monomeric GTP-Binding Proteins - biosynthesis; Neoplasm Staging; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Proliferating Cell Nuclear Antigen - biosynthesis; Prostaglandin-Endoperoxide Synthases - biosynthesis; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Transcription Factors - biosynthesis; Tumor Suppressor Protein p53 - biosynthesis

Molecular biological studies indicated that abnormal expression of cyclooxygenase-2(COX-2), p53, proliferating cell nuclear antigen(PCNA), and nm23 correlate with the development of gastric cancer, but the relationship between abnormal expression of above gene proteins and the biological behavior of gastric cancer was not yet clear. This study was designed to investigate the relationship between expressions of COX-2, p53, PCNA, and nm23 and the clinicopathological behavior in gastric cancer. The expressions of COX-2, p53, PCNA, and nm23 were detected by using immunohistochemical(SP) method. (1) The overexpression rate of COX-2 in gastric cancer was 70.4% (50/71), and the overexpression of COX-2 was correlated to tumor size, gross morphology, histological type, lymph node metastases, and clinicopathological stage of gastric cancer (P < 0.05, or P < 0.01). (2) The overexpression rates of p53 and PCNA in 71 surgically removed specimens from the patients with gastric cancer were 74.6% and 78.9%, respectively. And