Laser DNA flow cytometry in patients with ovarian epithelial tumors

Despite the use of new drugs in therapy of ovarian cancer, remote results remain unsatisfactory. Traditional prognostic factors, which are often subjective, do not reflect the individual features of a tumor in a certain patient. The authors compare classical prognostic factors, the data of laser DNA...

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Bibliographic Details
Published inKlinicheskaia laboratornaia diagnostika no. 4; p. 48
Main Authors Panichenko, I V, Bogatyrev, V N, Kozachenko, V P, Zhordaniia, K I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2002
Subjects
Aneuploidy
Cell Cycle
DNA - analysis
Epithelium - pathology
Female
Flow Cytometry
Humans
Lasers
Ovarian Neoplasms - chemistry
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Ploidies
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Summary:Despite the use of new drugs in therapy of ovarian cancer, remote results remain unsatisfactory. Traditional prognostic factors, which are often subjective, do not reflect the individual features of a tumor in a certain patient. The authors compare classical prognostic factors, the data of laser DNA flow cytometry, and the receptor status of the tumor. Tumor ploidy is the most informative independent prognostic factor: the period without relapses in patients with aneuploid tumors is significantly shorter in comparison with patients with diploid tumors. Study of tumor cell distribution by the cell cycle phases can also provide additional information for predicting the disease course in ovarian cancer.
ISSN:0869-2084