Glutamate decarboxylase activity and GABA binding by synaptic membranes of brain structure under stress in intact rats and rats with hormonal blockade of the hypothalamo-hypophyseal-adrenal cortex system

Under the inhibition of hypothalamo-pituitary-adrenal system function, as a result of prolonged hydrocortisone administration, the normal neurochemical reaction to stress, i.e. stimulating the formation of GABA (mediator that is basic among responsible ones for the realization of stress-limiting bra...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 73; no. 4; p. 84
Main Authors Myshunina, T M, Kononenko, V Ia
Format Journal Article
LanguageUkrainian
Published Ukraine 01.07.2001
Subjects
Adrenal Cortex - physiology
Animals
Brain - enzymology
gamma-Aminobutyric Acid - metabolism
Glutamate Decarboxylase - metabolism
Hypothalamo-Hypophyseal System
Male
Protein Binding
Rats
Rats, Wistar
Stress, Physiological - enzymology
Synaptic Membranes - enzymology
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Summary:Under the inhibition of hypothalamo-pituitary-adrenal system function, as a result of prolonged hydrocortisone administration, the normal neurochemical reaction to stress, i.e. stimulating the formation of GABA (mediator that is basic among responsible ones for the realization of stress-limiting brain function) was absent. In the medulla under such conditions an increase in the degree of GABA reception processes activation of comparing with the intact stressed rats was revealed and in the hippocamp of their changes was directivity reverse.