Effect of moxonidine on the cardiac chronotropic regulation in hypertensive rats SHR-SP

The administration of moxonidine for two weeks in a daily dose of 2 or 10 mg/kg (p.o.) reduced the cardiac sympathetic tone in stroke-prone spontaneously hypertensive rats (SHR-SP) by 24.3 +/- 7.3 and 32.2 +/- 10.2%, respectively. In addition, the treatment influenced the cardiac baroreflex by decre...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 64; no. 1; p. 42
Main Authors Khokhlova, O N, Murashov, A N, Lavrova, L N, Medvedev, O S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2001
Subjects
Adrenergic beta-Antagonists - pharmacology
Animals
Antihypertensive Agents - pharmacology
Atenolol - pharmacology
Atropine - pharmacology
Baroreflex - drug effects
Blood Pressure - drug effects
Heart Rate - drug effects
Imidazoles - pharmacology
Male
Muscarinic Antagonists - pharmacology
Parasympatholytics - pharmacology
Rats
Rats, Inbred SHR
Receptors, Adrenergic, beta-1 - drug effects
Sympatholytics - pharmacology
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Summary:The administration of moxonidine for two weeks in a daily dose of 2 or 10 mg/kg (p.o.) reduced the cardiac sympathetic tone in stroke-prone spontaneously hypertensive rats (SHR-SP) by 24.3 +/- 7.3 and 32.2 +/- 10.2%, respectively. In addition, the treatment influenced the cardiac baroreflex by decreasing the bradycardic plateau and increasing both bradycardic and tachycardic range. The baroreflex gain increased in a dose-dependent manner by 41.6 +/- 12.1 and 103.0 +/- 3.9%, respectively. These data indicate that moxonidine can modulate the cardiac autonomic (tonic and reflex) chronotropic control.
ISSN:0869-2092