The use of liposomal form of phenylimide of cis-aconitic acid in herpes therapy

The results of study of the antiviral activity and pharmacokinetics of phenylimide of cis-aconitic acid (PCAA) is presented. The 20% increase of the antiviral activity of PCAA incorporated into liposomes in comparison with the antiviral activity of the pure substance was shown. Liposomes with PCAA w...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 5; p. 58
Main Authors Kuchma, I Iu, Volianskiĭ, A Iu, Moskalenko, V F, Tkachuk, T V, Dobroskok, A I, Martynov, A V, Smelianskaia, M V, Peremot, S D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2000
Subjects
Aconitic Acid - administration & dosage
Aconitic Acid - analogs & derivatives
Aconitic Acid - pharmacokinetics
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacokinetics
Imides - administration & dosage
Imides - pharmacokinetics
Keratitis, Herpetic - drug therapy
Liposomes
Rabbits
Stereoisomerism
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Summary:The results of study of the antiviral activity and pharmacokinetics of phenylimide of cis-aconitic acid (PCAA) is presented. The 20% increase of the antiviral activity of PCAA incorporated into liposomes in comparison with the antiviral activity of the pure substance was shown. Liposomes with PCAA were tropic to lymphocytes and macrophages with maximum fluorescence being observed in the spleen, while empty liposomes were accumulated mainly in the liver. After the treatment with liposomal PCAA the symptoms of herpetic meningoencephalitis became less severe with 100% survival of the experimental animals. In the control group of rabbits 50% of the animals died, and in the surviving animals blindness or paralysis developed.
ISSN:0372-9311