A convenient method for laboratory synthesis of the N-([1-14Cpalmitoyl)ethanolamine, labeled by a fatty acid

Data concerning the synthesis of bioactive lipid compound N-([1-14C]-palmitoyl)ethanolamine labeled by 14C fatty acid are reported. The method is based on the ability of ethanolamine and fatty acid to the direct chemical condensation at 180 degrees C with yielding of N-acylethanolamine. The purifica...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 71; no. 6; p. 108
Main Authors Marhitykh, V M, Zhukov, O D, Artamonov, M V, Hula, N M
Format Journal Article
LanguageUkrainian
Published Ukraine 01.11.1999
Subjects
Carbon Radioisotopes
Chromatography, Gas
Phosphatidylethanolamines - chemical synthesis
Phosphatidylethanolamines - chemistry
Phosphatidylethanolamines - isolation & purification
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Summary:Data concerning the synthesis of bioactive lipid compound N-([1-14C]-palmitoyl)ethanolamine labeled by 14C fatty acid are reported. The method is based on the ability of ethanolamine and fatty acid to the direct chemical condensation at 180 degrees C with yielding of N-acylethanolamine. The purification of the end product by the double crystallization in ethanol allows to obtain chromatographically pure substance. The presented method of the labeled N-([1-14C]-palmitoyl)ethanolamine synthesis is simple and in extensive that's why it might be used in the area of biologically active compounds investigation.