Effect of acute alcoholic and acetaldehyde poisoning on lipid metabolism in the rat liver

Lipid metabolism in the liver of rats in acute alcohol (25% solution, intraperitoneally, 4 g/kg, 30 minutes) and acetaldehyde (5% solution, intraperitoneally, 0.266 g/kg, 30 minutes) intoxication has been studied. It has been revealed that with acute injection of ethanol into the livers of experimen...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 71; no. 1; p. 95
Main Authors Selevich, M I, Lelevich, V V
Format Journal Article
LanguageRussian
Published Ukraine 01.01.1999
Subjects
Acetaldehyde - poisoning
Acute Disease
Alcoholic Intoxication - metabolism
Animals
Cholesterol - metabolism
Injections, Intraperitoneal
Liver - metabolism
Male
Phosphatidylethanolamines - metabolism
Rats
Triglycerides - metabolism
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Summary:Lipid metabolism in the liver of rats in acute alcohol (25% solution, intraperitoneally, 4 g/kg, 30 minutes) and acetaldehyde (5% solution, intraperitoneally, 0.266 g/kg, 30 minutes) intoxication has been studied. It has been revealed that with acute injection of ethanol into the livers of experimental animals the level of cholesterol is decreased, the content of triacylglycerols and phosphatidylethanolamine is increased. Analogous changes in the concentration of lipid fractions have been also revealed after injection of acetaldehyde.