Natural and synthetic inhibitors of thrombin. I. Natural inhibitors

Structures and properties of main physiological (heparin, antithrombin III, heparin cofactor II) and nonphysiological (hirudin, thrombin-binding aptamers, cyclotheonamides) natural thrombin inhibitors and its fragments and synthetic analogs (hirugen, hirulogs, hirunorms, pentasaccharides, macrocycli...

Full description

Saved in:
Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 71; no. 1; p. 5
Main Authors Kibirev, V K, Gershkovich, A A
Format Journal Article
LanguageRussian
Published Ukraine 01.01.1999
Subjects
Antithrombin III - physiology
Antithrombins - pharmacology
Antithrombins - physiology
Carbohydrate Sequence
Fibrinolytic Agents - pharmacology
Heparin - physiology
Heparin Cofactor II - physiology
Hirudins - analogs & derivatives
Hirudins - pharmacology
Humans
Molecular Sequence Data
Oligosaccharides - pharmacology
Online AccessGet more information

Cover

More Information
Summary:Structures and properties of main physiological (heparin, antithrombin III, heparin cofactor II) and nonphysiological (hirudin, thrombin-binding aptamers, cyclotheonamides) natural thrombin inhibitors and its fragments and synthetic analogs (hirugen, hirulogs, hirunorms, pentasaccharides, macrocyclic alpha-keto amides) were reviewed. The molecular mechanisms of interaction of these compounds with thrombin and their anticoagulant activity at preclinical and clinical trials are discussed. The examined of natural thrombin inhibitors and their synthetic fragments and analogs are perspective for prophylaxis and treatment of different thrombo-embolic diseases.