Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients

Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an inci...

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Published inArquivos de neuro-psiquiatria Vol. 56; no. 4; p. 769
Main Authors Mielli, S R, Beitler, B, Galperin, C, Palou, V B, Livramento, J A, Machado, L dos R, Gomes, H R
Format Journal Article
LanguagePortuguese
Published Brazil 01.12.1998
Subjects
Adult
Cerebrospinal Fluid Proteins - analysis
Humans
Immunoglobulin G - blood
Lymphoma, Non-Hodgkin - blood
Lymphoma, Non-Hodgkin - cerebrospinal fluid
Lymphoma, Non-Hodgkin - complications
Nephelometry and Turbidimetry
Serum Albumin - analysis
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Summary:Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absence of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma.
ISSN:0004-282X