LYSOSOMICS: Functional Genomics of the Lysosome
Objective: For a long time the lysosome has been viewed as a static organelle that performs routine work for the cell, mostly pertaining to degradation and recycling of cellular waste. My group has challenged this view and used a systems biology approach to discover that the lysosome is subject to a...
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| Published in | MENA Report |
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| Format | Newsletter |
| Language | English |
| Published |
Camden
Disco Digital Media, Inc
23.09.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2219-0112 |
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| Summary: | Objective: For a long time the lysosome has been viewed as a static organelle that performs routine work for the cell, mostly pertaining to degradation and recycling of cellular waste. My group has challenged this view and used a systems biology approach to discover that the lysosome is subject to a global transcriptional regulation, is able to adapt to environmental clues, and acts as a signalling hub to regulate cell homeostasis. Furthermore, an emerging role of the lysosome has been identified in many types of diseases, including the common neurodegenerative disorders Parkinson~s and Alzheimers. These findings have opened entirely new fields of investigation on lysosomal biology, suggesting that there is a lot to be learned on the role of the lysosome in health and disease. |
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| ISSN: | 2219-0112 |