Intraop neuropathology consultation: tips and cases

In the predominant non-enhancing component of the glioma, the histology shows minimal mitotic activity and no vascular proliferation or necrosis, and it would be a CNS WHO grade two tumor (Fig. 1). The minor enhancing component looks more aggressive, with vascular proliferation, necrosis, and elevat...

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Bibliographic Details
Published inCAP Today Vol. 38; no. 9; pp. 18 - 22
Main Author Carpenter, Amy
Format Trade Publication Article
LanguageEnglish
Published Northfield College of American Pathologists 01.09.2024
Subjects
Antibodies
Brain cancer
Cysts
Glioma
Histology
Metastasis
Mutation
Neuropathology
Pathology
Patients
Pediatrics
Proteins
Tumors
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Summary:In the predominant non-enhancing component of the glioma, the histology shows minimal mitotic activity and no vascular proliferation or necrosis, and it would be a CNS WHO grade two tumor (Fig. 1). The minor enhancing component looks more aggressive, with vascular proliferation, necrosis, and elevated mitotic activity (Fig. 2). In his third case, Dr. Ballester showed a non-enhancing lesion (Fig. 7) for which a glioma is suspected, he said, though not a high-grade glioma because it is enhancement that correlates with the histologic characteristics of high-grade gliomas- vascular proliferation and necrosis. The histology is consistent with a diffuse glioma (Fig. 8) with no elevated mitotic activity, no microvascular proliferation, and no necrosis. Here too the histology is consistent with a diffuse glioma, "completely different just based on the location and the molecular characteristics of the tumor" (Fig. 10).
ISSN:0891-1525