Patients With Gout 20% More Likely to Undergo Lower Extremity Amputation

According to the researchers, patients with gout were more likely to undergo amputation, compared with those without gout, with an increased rate that remained even after adjusting for variables (adjusted HR = 1.2; 95% CI, 1.16-1.24). [...]we found that poor serum urate control is also independently...

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Bibliographic Details
Published inHealio Rheumatology pp. 46 - 47
Main Authors DeMarco, Paul J, Laday, Jason
Format Trade Publication Article
LanguageEnglish
Published Thorofare SLACK INCORPORATED 01.03.2022
Subjects
Amputation
Arthritis
Comorbidity
Diabetes
Financial disclosure
Kidney diseases
Rheumatism
Rheumatology
Veterans
United States > US
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Summary:According to the researchers, patients with gout were more likely to undergo amputation, compared with those without gout, with an increased rate that remained even after adjusting for variables (adjusted HR = 1.2; 95% CI, 1.16-1.24). [...]we found that poor serum urate control is also independently associated with amputation, suggesting that at least some of these procedures might be preventable. [...]research defining the role of select laboratory testing or imaging and the potential preventive role of urate lowering therapy in this context are warranted." - by Jason Laday PERSPECTIVE In their study, Mikuls and colleagues postulate whether gout should take a place alongside diabetes as having an association with lower extremity ischemia leading to lower extremity amputation (LEA), identifying gout as a modifiable risk factor to prevent progression towards this life-saving but deforming surgical intervention.
ISSN:2380-6818
2380-6834