New drug assessment with pharmaco- and toxicogenomics

Toxicogenomics can also be employed to facilitate investigative toxicity studies targeted at unexpected toxicities that occur in vivo. The currently employed strategies of animal-based toxicity testing rely upon blood chemistry and histopathology. These approaches often provide little insight into a...

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Bibliographic Details
Published inDrug Discovery & Development Vol. 5; no. 9; p. 29
Main Author Rininger, Joseph A
Format Trade Publication Article
LanguageEnglish
Published Rockaway Advantage Business Media 01.10.2002
Subjects
Candidates
Gene expression
Genomics
Pharmaceutical industry
Product development
Studies
Success
Toxicity
Toxicology
United Kingdom > UK
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Summary:Toxicogenomics can also be employed to facilitate investigative toxicity studies targeted at unexpected toxicities that occur in vivo. The currently employed strategies of animal-based toxicity testing rely upon blood chemistry and histopathology. These approaches often provide little insight into a compound's molecular mechanism of toxicity. This lack of information complicates the interpretation of toxicity data, especially when there is conflicting toxicity in different animal species.
ISSN:1524-783X
1558-6022