Enhancing the Sensitivity of Atmospheric Pressure Ionization Mass Spectrometry Using Flow Modulated Gas Chromatography

Peak intensity enhancement is one highly desirable outcome of comprehensive two-dimensional gas chromatography (GC×GC). When coupled to mass spectrometry (MS), such enhancement is usually achieved with a thermal modulator using a technique called cryogenic zone compression (CZC). Differential flow m...

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Bibliographic Details
Published inLC GC North America pp. 15 - 19
Main Authors Jobst, Karl J, Seeley, John V, Reiner, Eric J, Mullin, Lauren, Ladak, Adam
Format Magazine Article
LanguageEnglish
Published Monmouth Junction MultiMedia Healthcare Inc 01.10.2018
Subjects
Atmospheric pressure
Chromatography
Compression zone
Coupling (molecular)
Effluents
Experiments
Flow velocity
Gas chromatography
High flow
Ionization
Ions
Mass spectrometers
Mass spectrometry
Modulation
Organic chemistry
PCB
Pollutants
Polychlorinated biphenyls
Scientific imaging
Sensitivity
Sensitivity analysis
Sensitivity enhancement
Spectrometers
Spectroscopy
United States > US
Michigan
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Summary:Peak intensity enhancement is one highly desirable outcome of comprehensive two-dimensional gas chromatography (GC×GC). When coupled to mass spectrometry (MS), such enhancement is usually achieved with a thermal modulator using a technique called cryogenic zone compression (CZC). Differential flow modulation is a simple and cost-effective alternative to thermal modulation, but the requisite high flow rates are generally perceived as being incompatible with most (electron ionization [EI] and chemical ionization [CI]) mass spectrometers. The past decade has witnessed resurgent interest in coupling GC to atmospheric pressure chemical ionization (APCI), which requires high gas flows to assist ionization. This article reports on the modification of a GC-APCI system with a flow modulator and evaluates its potential to enhance the sensitivity towards selected trace organics.
ISSN:1527-5949
1939-1889