Fatal Sepsis Associated with Bacterial Contamination of Platelets - Utah and California, August 2017

Platelet-transmitted bacterial infections persist as a cause of transfusion-associated morbidity and mortality. Whole genome sequencing was used to identify the source of fatal sepsis in three transfusion recipients resulting from bacterial contamination (Clostridium perfringens in Utah and Klebsiel...

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Bibliographic Details
Published inMMWR. Morbidity and Mortality Weekly Report Vol. 67; no. 25; pp. 718 - 722
Main Authors Horth, Roberta Z, Jones, Jefferson M, Kim, Janice J, Lopansri, Bert K, Ilstrup, Sarah J, Fridey, Joy, Kelley, Walter E, Stramer, Susan L, Nambiar, Ashok, Ramirez-Avila, Lynn, Nichols, Amy, Garcia, Wendy, Oakeson, Kelly F, Vlachos, Nicholas, McAllister, Gillian, Hunter, Robert, Nakashima, Allyn K, Basavaraju, Sridhar V
Format Report
LanguageEnglish
Published Atlanta U.S. Center for Disease Control 29.06.2018
Subjects
Antibiotics
Bacteria
Bacterial infections
Blood & organ donations
Blood platelets
Clostridium perfringens
Contamination
Deactivation
Family medical history
Fatalities
Gene sequencing
Genomes
Hospitals
Inactivation
Infections
Infectious diseases
Klebsiella
Klebsiella pneumoniae
Leukemia
Medical laboratories
Morbidity
Neutropenia
Platelets
Public health
Sepsis
Transfusion
Zoonoses
San Francisco California
United States > US
California
Utah
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Summary:Platelet-transmitted bacterial infections persist as a cause of transfusion-associated morbidity and mortality. Whole genome sequencing was used to identify the source of fatal sepsis in three transfusion recipients resulting from bacterial contamination (Clostridium perfringens in Utah and Klebsiella pneumoniae in California) of platelet products. Implementation of evidence-based strategies, including pathogen inactivation, rapid detection devices, and modified screening of bacterial culture protocols can mitigate the risk for bacterial contamination of platelets.
ISSN:0149-2195
1545-861X