Particle Sizing: An Established PAT for Continuous Manufacturing

Particle sizing technology is used to exemplify the integration of real-time monitors within a continuous process to exert the necessary, automated control and ensure consistent product quality. _________________________________________________________________________________ Batch vs. continuous ma...

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Bibliographic Details
Published inPharmaceutical Processing
Main Author Warman, Martin
Format Trade Publication Article
LanguageEnglish
Published Rockaway Advantage Business Media 23.08.2017
Subjects
Automation
Batch processes
Clinical trials
Cost control
Drugs
Efficiency
Inventory
Manufacturing
Particle size
Pharmaceutical industry
Process controls
Product quality
Raw materials
Studies
Supply chains
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Summary:Particle sizing technology is used to exemplify the integration of real-time monitors within a continuous process to exert the necessary, automated control and ensure consistent product quality. _________________________________________________________________________________ Batch vs. continuous manufacture In a true batch process, raw materials are added at the start of the processing period and the product is discharged at the end. [...]with a traditional batch approach, as the scale of production is increased towards commercialization, the design space for the process shifts. [...]PAT measures much larger sample sizes than are routinely sampled in endpoint testing and, when appropriately implemented, can provide a robust assessment of finished product quality. [...]The benefits of CM are well-proven by, for example, the bulk chemicals sector, but for the pharmaceutical industry, a switch from batch to continuous processing has the potential to address certain specific issues.
ISSN:1049-9156