Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyr rolo[1,2-c]imidazol-1-ones: A new class of Neuropeptide S antagonists
A new class of selective NPS antagonist was developed starting from a commercially available product identified by screening activities. Experimental NMR observations and computational experiments allowed the discovery of a new class of derivatives. 5-Phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-d...
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Published in | Bioorganic & medicinal chemistry letters Vol. 20; no. 24; pp. 7308 - 7311 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
15.12.2010
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Online Access | Get full text |
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Summary: | A new class of selective NPS antagonist was developed starting from a commercially available product identified by screening activities. Experimental NMR observations and computational experiments allowed the discovery of a new class of derivatives. 5-Phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyr rolo[1,2-c]imidazol-1-one represents a new lead compound in the NPS antagonist field. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
ISSN: | 0960-894X |
DOI: | 10.1016/j.bmcl.2010.10.067 |