Towards a modern definition of vitamin E&; mdash; evidence for a quinone hypothesis

We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, alpha -tocopherol quinone (ATQ); an oxidative metabolite of alpha -tocopherol. ATQ is a potent cellular protectant against oxidative stress, whose biological activity is dependent upon its ability...

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Published inBioorganic & medicinal chemistry letters Vol. 22; no. 1; pp. 391 - 395
Main Authors Shrader, William D, Amagata, Akiko, Barnes, Adam, Hinman, Andrew, Jankowski, Orion, Lee, Edgar, Kheifets, Viktoria, Komatsuzaki, Ryo, Mollard, Paul, Murase, Katsuyuki, Rioux, Patrice, Wesson, Kieron, Miller, Guy
Format Journal Article
LanguageEnglish
Published 01.01.2012
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Summary:We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, alpha -tocopherol quinone (ATQ); an oxidative metabolite of alpha -tocopherol. ATQ is a potent cellular protectant against oxidative stress, whose biological activity is dependent upon its ability to undergo reversible two-electron redox cycling. ATQ is orally bioavailable, with a favorable pharmacokinetic profile and has demonstrated a beneficial clinical response in patients with Friedreich's ataxia. ATQ is a member of a broader class of vitamin E derived quinone metabolites which may be ascribable in whole or in part to the activity of vitamin E.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0960-894X
DOI:10.1016/j.bmcl.2011.10.117