Sulfonamides as selective oestrogen receptor [beta] agonists

A series of p-hydroxybenzenesulphonamides ER[beta] receptor agonists were discovered and several compounds identified had excellent selectivity over the related ER[alpha] receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent star...

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Published inBioorganic & medicinal chemistry letters Vol. 21; no. 19; pp. 5680 - 5683
Main Authors Roberts, Lee R, Armor, Duncan, Barker, Carolyn, Bent, Andrew, Bess, Kirstin, Brown, Alan, Favor, David A, Ellis, David, Irving, Stephen L, MacKenny, Malcolm, Phillips, Chris, Pullen, Nick, Stennett, Adam, Strand, Linda, Styles, Michelle
Format Journal Article
LanguageEnglish
Published 01.10.2011
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Summary:A series of p-hydroxybenzenesulphonamides ER[beta] receptor agonists were discovered and several compounds identified had excellent selectivity over the related ER[alpha] receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ER[beta] agonists.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-1
ISSN:0960-894X
DOI:10.1016/j.bmcl.2011.08.041