Characterization of the micA gene encoding a small regulatory sigma super(E)-dependent RNA in Salmonella enterica serovar Typhimurium

The role of MicA (repressing small regulatory non-coding RNAs of two Salmonella porins) was determined in virulence of Salmonella enterica serovar Typhimurium. Transcriptional analysis revealed that the expression of the micA gene is driven by a single sigma super(E)-dependent promoter, micAp. Its a...

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Published inFolia microbiologica Vol. 56; no. 1; pp. 59 - 65
Main Authors Homerova, D, Rezuchova, B, Stevenson, A, Skovierova, H, Roberts, M, Kormanec, J
Format Journal Article
LanguageEnglish
Published 01.01.2011
Subjects
Salmonella enterica
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Summary:The role of MicA (repressing small regulatory non-coding RNAs of two Salmonella porins) was determined in virulence of Salmonella enterica serovar Typhimurium. Transcriptional analysis revealed that the expression of the micA gene is driven by a single sigma super(E)-dependent promoter, micAp. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the micA mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-011-0014-4