Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum

Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO super(-), and ONOO super(-) derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chem...

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Published inOcean and polar research Vol. 33; no. 2; pp. 185 - 191
Main Authors Lee, JI, Kong, C-S, Jung, ME, Hong, J W, Noh, I, Seo, Y
Format Journal Article
LanguageKorean
Published 01.06.2011
Subjects
Limonium
Marine
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Abstract Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO super(-), and ONOO super(-) derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO super(-) were 56, 37, 56, and 54%, respectively, at a concentration of 1 mu M. On the other hand, the inbihition ratios of compounds 1-4 against ONOO super(-) generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.
AbstractList Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO super(-), and ONOO super(-) derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO super(-) were 56, 37, 56, and 54%, respectively, at a concentration of 1 mu M. On the other hand, the inbihition ratios of compounds 1-4 against ONOO super(-) generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.
Author Hong, J W
Kong, C-S
Jung, ME
Noh, I
Lee, JI
Seo, Y
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Title Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum
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