Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum

• Published in: Ocean and polar research Vol. 33; no. 2; pp. 185 - 191
• Main Authors: Lee, JI, Kong, C-S, Jung, ME, Hong, J W, Noh, I, Seo, Y
• Format: Journal Article
• Language: Korean
• Published: 01.06.2011
• Subjects: Limonium; Marine
• ISSN: 1598-141X; 2234-7313
• DOI: 10.4217/OPR.2011.33.2.185

Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO super(-), and ONOO super(-) derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO super(-) were 56, 37, 56, and 54%, respectively, at a concentration of 1 mu M. On the other hand, the inbihition ratios of compounds 1-4 against ONOO super(-) generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.