Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer

A 45-year-old man complaining of cough, dyspnea, and difficulty in swallowing was referred to our hospital. Chest CT scan showed a mediastinal mass compressing the trachea. He was diagnosed with poorly differentiated lung carcinoma by percutaneous needle biopsy. Bronchoscopy and upper gastrointestin...

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Published inCase reports in oncology Vol. 4; no. 2; pp. 350 - 357
Main Authors Honda, Takayuki, Tsuzaki, Yoshihito, Mitaka, Keiko, Fukasawa, Kazuhiro, Miyashita, Yoshihiro, Marino, Kan, Saito, Akitoshi, Oyama, Toshio, Inase, Naohiko
Format Report
LanguageEnglish
Published 01.01.2011
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Summary:A 45-year-old man complaining of cough, dyspnea, and difficulty in swallowing was referred to our hospital. Chest CT scan showed a mediastinal mass compressing the trachea. He was diagnosed with poorly differentiated lung carcinoma by percutaneous needle biopsy. Bronchoscopy and upper gastrointestinal endoscopy revealed a tracheoesophageal fistula (TEF). Long-lasting febrile neutropenia made it impossible to continue chemotherapy, but a course of radiotherapy (total 61 Gy) was completed. The next endoscopy revealed closure of the TEF. Chemoradiotherapy (CRT) has been reported to close TEF in esophageal cancer, but the risk of a CRT-induced worsening of the fistula has dissuaded physicians from using CRT to treat TEF in lung cancer patients. CRT may serve as a palliative treatment for TEF in lung cancer as well as esophageal cancer.
Bibliography:ObjectType-Case Study-2
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SourceType-Reports-1
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ISSN:1662-6575
DOI:10.1159/000330368