1,3-Capryloyl-2-arachidonoyl glycerol activates a-secretase activity and suppresses Ab40 secretion in A172 cells

Alzheimer's disease (AD) is characterized by the deposition of amyloid b-peptide (Ab), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We an...

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Published inNeuroscience letters Vol. 450; no. 3; pp. 324 - 326
Main Authors Tanabe, Chiaki, Ebina, Maiko, Asai, Masashi, Futai, Eugene, Sasagawa, Noboru, Katano, Kenji, Fukami, Harukazu, Ishiura, Shoichi
Format Journal Article
LanguageEnglish
Published 06.02.2009
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Summary:Alzheimer's disease (AD) is characterized by the deposition of amyloid b-peptide (Ab), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We analyzed the effects of triglycerides combined with polyunsaturated fatty acids (PUFAs) and/or caprylic acids on APP proteolysis. Our results showed that 1,3-capryloyl-2-arachidonoyl glycerol (8A8) moderately increased a-secretase activity (18%) in A172 cells. b-Secretase activity was not statistically significantly changed in HEK293 cells stably expressing BACE1. However, Ab40 secretion decreased by 22%. Thus, we conclude that 8A8 is a useful lipid compound for activating a-secretase activity and suppressing Ab40 secretion.
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ISSN:0304-3940
DOI:10.1016/j.neulet.2008.11.039