Cytotoxic Clerodane Diterpenoids and Their Hydrolysis Products from Casearia nigrescens from the Rainforest of Madagascarn

Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDC1. The structures of compounds 1-4...

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Published inJournal of natural products (Washington, D.C.) Vol. 70; no. 2
Main Authors Williams, R B, Norris, A, Miller, J S, Birkinshaw, C, Ratovoson, F, Andriantsiferana, R, Rasamison, V E, Kingston, D G
Format Journal Article
LanguageEnglish
Published 01.02.2007
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Summary:Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDC1. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an 1C50 range of 0.83-1.4 mM.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0163-3864