KLF1 regulates BCL11A expression and g- to b-globin gene switching

We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human g-globin/b-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating b-globin and indirectly repressing g-globin gene...

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Published inNature genetics Vol. 42; no. 9; pp. 742 - 744
Main Authors Zhou, Dewang, Liu, Kaimao, Sun, Chiao-Wang, Pawlik, Kevin M, Townes, Tim M
Format Journal Article
LanguageEnglish
Published 01.09.2010
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Summary:We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human g-globin/b-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating b-globin and indirectly repressing g-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with b-thalassemia or sickle cell disease.
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ISSN:1061-4036
DOI:10.1038/ng.637