Expression of Dickkopf-3 in Non-small Cell Lung Cancer and Its Significance

• Published in: Zhongliu fangzhi yanjiu Vol. 37; no. 5; pp. 528 - 530
• Main Authors: Cai, M, Luo, C-G, Xiong, W-N, Cao, Y
• Format: Journal Article
• Language: Chinese
• Published: 25.05.2010
• ISSN: 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2010.05.011

Objective To investigate the correlation between the expression of Dickkopf-3 (Dkk-3) and the clinicopathologic features of non-small cell lung cancer (NSCLC). Methods High sensitive SP immunohistochemical method was used to detect the expression of Dkk-3 in 50 NSCLC specimens and 20 benign lesion lung tissues. Results Dkk-3 was expressed in 26 out of 50 human non-small cell lung cancer tissues, which was significantly lower than that in benign lesion tissues (P<3.05). Furthermore, the decreased expression of Dkk-3 in lung cancer tissues was positive correlation with lymph migration and clinical stage, while no correlation was observed between the expression of Dkk-3 and sex or histological classification in non-small cell lung cancer. Conclusion Dkk-3 gene may be a novel candidate of tumor-suppressor, and its inhibition may contribute to the progress of non-small cell lung cancer.