Effect of thymopentin on the production of cytokines, heat shock proteins, and NF-kB signaling proteins

In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signaling proteins NF-*kB, phNF-*kB, and I*kB-*a in lymphoid cells of male NMRI mice was studied. Activation of production...

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Published inBiology bulletin of the Russian Academy of Sciences Vol. 35; no. 4; pp. 362 - 367
Main Authors Novoselova, E G, Lunin, S M, Khrenov, M O, Cherenkov, D A, Novoselova, T V, Lysenko, E A, Fesenko, E E
Format Journal Article
LanguageEnglish
Published 01.08.2008
Subjects
Body weight
Cell activation
Cytokines
Heat shock proteins
Hormones
Hsp70 protein
Hsp90 protein
Interleukin 10
Interleukin 2
Interleukin 6
Lymphocytes
Lymphoid cells
Macrophages
Nitric oxide
Peritoneum
Phosphorylation
Signal transduction
Spleen
Thymus
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Summary:In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signaling proteins NF-*kB, phNF-*kB, and I*kB-*a in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1*a, IL-2, IL-6, IL-10, and IFN-*g), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15*mg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-*kB signaling pathway, which is most pronounced at the NF-*kB phosphorylation stage.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359008040055