Increased Level of b-Amyloid in the Brain of Bulbectomized Mice

Six weeks after bilateral olfactory bulbectomy, a peptide with molecular weight of 4 kD was revealed in extracts of the neocortex and hippocampus from mice. Using monoclonal antibodies 4G8, this peptide was identified as b-amyloid. Its level was significantly higher in the bulbectomized animals than...

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Published inBiochemistry (Moscow) Vol. 69; no. 2; pp. 176 - 180
Main Authors Aleksandrova, IYu, Kuvichkin, V V, Kashparov, IA, Medvinskaya, NI, Nesterova, I V, Lunin, S M, Samokhin, AN, Bobkova, N V
Format Journal Article
LanguageEnglish
Published 01.02.2004
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Summary:Six weeks after bilateral olfactory bulbectomy, a peptide with molecular weight of 4 kD was revealed in extracts of the neocortex and hippocampus from mice. Using monoclonal antibodies 4G8, this peptide was identified as b-amyloid. Its level was significantly higher in the bulbectomized animals than in sham-operated mice. The bulbectomized mice displayed sharp impairment in spatial memory when tested in the Morris water maze. The results suggest that bulbectomy initiates in the brain a pathological process similar to human Alzheimer's disease in location, biochemistry, and behavioral manifestations.
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ISSN:0006-2979
1608-3040
DOI:10.1023/B:BIRY.0000018948.04559.ab