The role of glucocorticoid in SIRPa and SHP-1 gene expression in AIHA patients

The aim of this work was to evaluate the regulation of SIRPa, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRPa and SHP-1 gene expression and erythrophagocytosis in vitro. SIRPa and SHP-1 expr...

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Published inImmunopharmacology and immunotoxicology Vol. 31; no. 4; pp. 636 - 640
Main Authors de Almeida, AC, Barbosa, S M, de Lourdes Barjas-Castro, M, Olalla-Saad, ST, Condino-Neto, A
Format Journal Article
LanguageEnglish
Published 01.12.2009
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Summary:The aim of this work was to evaluate the regulation of SIRPa, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRPa and SHP-1 gene expression and erythrophagocytosis in vitro. SIRPa and SHP-1 expression was higher in monocytes from AIHA patients compared with normal, returning to normal after glucocorticoid therapy. SIRPa and SHP-1 mRNA expression was upregulated in healthy monocytes treated with dexamethasone compared with basal; however, the erythrophagocytic ability was not altered. Our results point to a minor role of SIRPa and SHP-1 in determining AIHA.
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ISSN:0892-3973
DOI:10.3109/08923970902939256