Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the b super(S)/Benin haplotype

There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the b super(S)/Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the super(A)g-499...

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Published inAmerican journal of hematology Vol. 80; no. 1; pp. 79 - 80
Main Authors Patrinos, George P, Samperi, Piera, Nigro, Luca lo, Kollia, Panagoula, Schiliro, Gino, Papadakis, Manoussos N
Format Journal Article
LanguageEnglish
Published 01.01.2005
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Summary:There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the b super(S)/Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the super(A)g-499 T1A variation in sickle cell anemia chromosomes of Sicilian and North African origin bearing the b super(S)/Benin haplotype. Being absent from North American b super(S)/Benin chromosomes, which were studied previously, this variation is indicative for the molecular heterogeneity of the b super(S)/Benin haplotype. Am. J. Hematol. 80:79-80, 2005.
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ISSN:0361-8609
DOI:10.1002/ajh.20400