Review on Protein Identification Approaches Based on Tandem Mass Spectrometry

One of the main objectives of proteomics is to identify and quantify proteins in a tissue or a cell. Tandem mass spectrum has been proved to be a powerful tool to achieve this goal. This paper presents a review on the protein identification approaches based on tandem mass spectrometry, including dat...

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Published inJisuanji Kexue yu Tansuo / Journal of Computer Science and Frontiers Vol. 4; no. 2; pp. 97 - 107
Main Authors Qiao, Yantao, Miao, Jiazheng, Sun, Shiwei, Liu, Jingang, Bu, Dongbo
Format Journal Article
LanguageChinese
Published 01.02.2010
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Summary:One of the main objectives of proteomics is to identify and quantify proteins in a tissue or a cell. Tandem mass spectrum has been proved to be a powerful tool to achieve this goal. This paper presents a review on the protein identification approaches based on tandem mass spectrometry, including database searching methods, De Novo methods, PST (peptide sequence tag) methods, and spectra library methods. It also introduces the research on peptide fragmentation principle, amino acids neutral losses, and peptide identification. Finally, the viewpoints on the development of mass spectrum techniques are described.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1673-9418
DOI:10.3778/j.issn.1673-9418.2010.02.001