Synthesis of 1,1,3-Polyfunctionalized Cyclobutane Derivatives from the Reaction of Sulfur Ylides with Bicyclo1.1.0butanes

• Published in: Organic letters Vol. 26; no. 36; p. 7525
• Main Authors: Wang, Jing, Xiang, Chaowei, Luo, Fang, Zeng, Linghui, Zhang, Chong, Zhang, Jiankang, Zhu, Huajian, He, Ruoyu, Shao, Jiaan
• Format: Journal Article
• Language: English
• Published: 13.09.2024
• ISSN: 1523-7052; 1523-7052
• DOI: 10.1021/acs.orglett.4c02388

1,1,3-Polyfunctionalized cyclobutane derivatives have been synthesized from sulfur ylides and bicyclo[1.1.0]butanes (BCBs). This protocol operates under mild reaction conditions without the need for catalysts, generally producing moderate to good yields of syn-addition derivatives with structural diversity. An unexpected intramolecular rearrangement mechanism has also been proposed.1,1,3-Polyfunctionalized cyclobutane derivatives have been synthesized from sulfur ylides and bicyclo[1.1.0]butanes (BCBs). This protocol operates under mild reaction conditions without the need for catalysts, generally producing moderate to good yields of syn-addition derivatives with structural diversity. An unexpected intramolecular rearrangement mechanism has also been proposed.