Modular Assembly of Pyrrolo3,4-cisoquinolines through Rh-Catalyzed Cascade C-H Activation/Annulation of O-Methyl Aryloximes with Maleimides

• Published in: Journal of organic chemistry Vol. 89; no. 12; p. 8447
• Main Authors: Wu, Yinsong, Liu, Yanan, Kong, Yangzilin, Wu, Mengdi, Wang, Demao, Shang, Yongjia, He, Xinwei
• Format: Journal Article
• Language: English
• Published: 21.06.2024
• ISSN: 1520-6904; 1520-6904
• DOI: 10.1021/acs.joc.4c00324

An efficient and practical strategy for the construction of pyrrolo[3,4-c]isoquinolines via Rh(III)-catalyzed cascade C-H activation and subsequential annulation process from easily available O-methyl aryloximes and maleimides has been disclosed. This facile protocol does not require any inert atmosphere protection with good efficiency in a low loading of catalyst and exhibits good functional group tolerance and broad substrate scope. Notably, the as-prepared products show potential photophysical properties.An efficient and practical strategy for the construction of pyrrolo[3,4-c]isoquinolines via Rh(III)-catalyzed cascade C-H activation and subsequential annulation process from easily available O-methyl aryloximes and maleimides has been disclosed. This facile protocol does not require any inert atmosphere protection with good efficiency in a low loading of catalyst and exhibits good functional group tolerance and broad substrate scope. Notably, the as-prepared products show potential photophysical properties.