ULTRAFAST TWO-DIMENSIONAL ION SEPARATIONS BASED ON ION MOBILITY-TIME-OF-FLIGHT MASS SPECTROMETRY: FROM BIOTECHNOLOGY TO NANOTECHNOLOGY

To advance the information content in biotechnology and nanotechnology studies using mass spectrometry (MS) techniques, two-dimensional (2D) post-ionization separations combining ion mobility (IM) with time-of-flight MS (IM-TOFMS) are described The added data dimensionality consists of ion structura...

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Published inRevista Brasileira de Aplicacoes de Vacuo (Brazilian Journal of Vacuum Applications) Vol. 24; no. 1; pp. 3 - 9
Main Authors McLean, J A, Schultz, J A, Ugarov, M V, Egan, T F, Russell, D H
Format Magazine Article
LanguagePortuguese
Published 01.01.2005
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Summary:To advance the information content in biotechnology and nanotechnology studies using mass spectrometry (MS) techniques, two-dimensional (2D) post-ionization separations combining ion mobility (IM) with time-of-flight MS (IM-TOFMS) are described The added data dimensionality consists of ion structural information based on the ion collision cross-section determined by IM with accurate mass measurements obtained by TOFMS. The basic theory of IM and practical implementation in IM-MS instrumentation is discussed and described in the context of high throughput separations (,us-ms), peptide and post-translational modification (PTM) identification, and structural deter-minations, for applications ranging from proteomics and tissue imaging, to characterization of carbon nanotubes.
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ISSN:0101-7659